VMWare is a powerful application which allows users the ability to run a virtualized Operating System from inside their main OS. This program is not only processor and RAM intensive but puts significant load on the storage subsystem with deep, heavy read/write IO requests to the drive. To help give you a general idea on the performance improvements from running a RAM Drive we have timed the time it takes to load XP SP3 from inside VMWare.
As you can see the BX300 does post some pretty decent numbers for a BX drive but like any SATA drive we would be sorely tempted to RAID them if we were doing serious work in VMWare.